Peptide

Ipamorelin

Gentle growth hormone pulse

A selective growth hormone secretagogue that stimulates GH release without significant effects on cortisol or prolactin. Known for its clean side effect profile.

Mechanisms

GH secretagogue receptor activation
Ghrelin mimetic action
Selective pituitary stimulation

Dosing

Typical dose

200–300mcg

Timing

Administer on empty stomach. Often combined with CJC-1295 for synergistic effects.

Synergies

CJC-1295 No DAC

Ipamorelin and CJC-1295 together maximize GH pulse amplitude and duration

Strong

Sermorelin

Ipamorelin and Sermorelin provide complementary GH secretagogue effects

Moderate

Tesamorelin

Tesamorelin and Ipamorelin combine for enhanced GH/fat loss effects

Moderate

Research

Review2014

Growth hormone secretagogue receptor agonism enhances sleep quality

Copinschi G et al·Sleep Medicine Reviews

Ipamorelin and similar GHRPs improve slow-wave sleep and GH pulsatility