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Peptide

MOTS-c

Mitochondrial exercise mimetic

A mitochondrial-derived peptide that mimics exercise effects at the cellular level. Improves metabolic function and insulin sensitivity.

Mechanisms

  • AMPK activation
  • Mitochondrial function
  • Metabolic regulation
  • Exercise mimetic

Dosing

Typical dose

5–10mg

Timing

3-5x weekly administration. Acts as an exercise mimetic at cellular level.

Synergies

SS-31 (Elamipretide)

MOTS-c and SS-31 both support mitochondrial function synergistically

Strong

Interactions

Metformin

MOTS-c and Metformin both activate AMPK - may be redundant

Note

Research

Cell study2015

MOTS-c: A mitochondrial-encoded peptide regulates energy metabolism

Lee C et al·Cell Metabolism

MOTS-c regulates metabolic homeostasis and acts as an exercise mimetic