stillwork
Supplement

Metformin

AMPK activating longevity drug

A diabetes drug being studied for longevity effects through AMPK activation and various metabolic benefits.

Mechanisms

  • AMPK activation
  • Glucose regulation
  • mTOR inhibition
  • Longevity pathways

Dosing

Typical dose

500–1500mg

Timing

Prescription required. Consider for longevity protocols under medical supervision.

Interactions

NMN (Nicotinamide Mononucleotide)

Metformin may reduce some benefits of NMN - timing matters

Note
Berberine

Berberine and Metformin have similar mechanisms - use caution combining

Caution
MOTS-c

MOTS-c and Metformin both activate AMPK - may be redundant

Note