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Supplement

Berberine

Natural glucose optimizer

A plant alkaloid with powerful effects on glucose metabolism, comparable to metformin. Supports metabolic health.

Mechanisms

  • AMPK activation
  • Glucose metabolism
  • Gut microbiome modulation
  • Lipid support

Dosing

Typical dose

500–1500mg

Timing

Take with meals. Split dosing 2-3x daily. GI adjustment period.

Synergies

Sulforaphane

Berberine and Sulforaphane both activate metabolic and protective pathways

Moderate

Interactions

Metformin

Berberine and Metformin have similar mechanisms - use caution combining

Caution
Vitamin B12 (Methylcobalamin)

Berberine may reduce B12 absorption with long-term use

Note

Research

RCT2008

Efficacy of berberine in patients with type 2 diabetes

Yin J et al·Metabolism

Berberine produced similar glucose and HbA1c reductions compared to metformin