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Supplement

NMN (Nicotinamide Mononucleotide)

Direct NAD+ precursor

A direct precursor to NAD+ with good bioavailability. Supports cellular energy, DNA repair, and healthy aging.

Mechanisms

  • NAD+ synthesis
  • Sirtuin support
  • Cellular energy
  • DNA repair

Dosing

Typical dose

250–500mg

Timing

Morning dosing. Sublingual absorption may be superior.

Synergies

Apigenin

NMN and Apigenin support NAD+ through synthesis and preservation

Strong
NR (Nicotinamide Riboside)

NMN and NR both support NAD+ levels through different pathways

Moderate

Interactions

Metformin

Metformin may reduce some benefits of NMN - timing matters

Note

Research

Animal study2016

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline

Mills KF et al·Cell Metabolism

NMN supplementation enhanced energy metabolism and physical activity in aged mice